The Yellow Submarine picked up a big win away from home on Thursday night, defeating Stade-Rennais after a chaotic game to top their Europa League group, and they are now looking for a big three points on the road in La Liga.
Real Madrid followed up a La Liga draw with Real betis last weekend with as 3-2 win over Union Berlin in the Champions League this week. Los Blancos currently sit second in the table, and they came into this weekend two points behind Girona.
Villarreal have played well against Real Madrid over the last couple of years, but they must improve on the brittle performance they produced against Real Sociedad last weekend.
The Yellows are currently in 14th place, coming into this weekend no less than 13 points off sixth place after a disappointing start to the season.
As ever, we invite you to join the conversation before, during and after this game in the comments section below.